Manifestación inicial atípica de una poliposis poco frecuente, el síndrome de Cowden / Unusual presenting manifestation of a rare polyposis, Cowden syndrome

No disponible

Herramientas / Tools

No disponible

¿Somos lo que comemos? Un estudio sobre la composición tisular y microbiológica de la carne picada de vacuno / Are we what we eat? A study of the tissue composition and microbiology of minced beef

En los últimos años en nuestro país se ha incrementado el consumo de carne picada, como reflejo de la actual crisis económica. Con el objeto de conocer la composición tisular y microbiológica de estos preparados cárnicos, se diseñó un estudio en el que se adquirieron siete envases de carne picada de vacuno en grandes superficies elegidas al azar, en el territorio de la comunidad de Madrid. Estos casos fueron procesados de forma convencional (fijación en formol e inclusión en parafina) para realizar un examen de su composición tisular y evaluar su estado de preservación con métodos convencionales de microscopía óptica. Se procedió a realizar antes de la fijación tisular, un cultivo microbiológico adicional. Los datos obtenidos reflejan en general la existencia de productos alimentarios de baja calidad y mal preservados, contaminados frecuentemente con flora bacteriana de tipo fecal (AU)

During recent years, probably due to the economic crisis, there has been an increase in the consumption of minced beef in Spain. A study was carried out to determine the tissue and microbiological composition of the minced beef on sale. Seven packets were bought randomly from shops throughout the region of Madrid and their contents processed with formalin fixation and paraffin embedding and examined by optical microscopy to examine tissue composition and the state of preservation. A microbiological study was also carried out. We found that these meat products were of poor quality, badly preserved and frequently contaminated with faecal bacteria (AU)

Fine needle aspiration cytology of Castleman disease, plasma cell type. A report of three cases / Punción aspiración con aguja fina de la enfermedad de Castleman, tipo plasmocelular. Descripción de 3 casos

Plasma cell type Castleman disease (PC-CD) may present with multicentric lymph node involvement or as a solitary mass. It is a rare condition and there are very few reports of its cytology and no descriptions of aspiration cytology findings in the plasma cell type. We evaluated three patients in which the possibility of malignant lymphoma had been considered clinically. Cytology revealed features of lymphoid follicular hyperplasia with numerous plasma cells and no signs of malignancy. Surgical excision revealed features of PC-CD. The cytology of PC-CD shows the benign features characteristic of a reactive lymphoid pattern with numerous plasma cells. When combined with clinical and image findings, a preoperative diagnosis could be made (AU)

La enfermedad de Castleman de tipo plasmocelular (PC-CD) puede presentarse como afectación ganglionar multicéntrica o como lesión solitaria. Se trata de una entidad infrecuente, y no existen descripciones citológicas en material de punción de esta variante. Evaluamos 3 pacientes, y en los 3 casos la posibilidad de un linfoma fue considerada clínicamente. El estudio citológico reveló rasgos de hiperplasia folicular linfoide con numerosas células plasmáticas, sin signos de malignidad. La resección quirúrgica mostro rasgos de PC-CD. La citología de PC-CD muestra un patrón linfoide reactivo con numerosas células plasmáticas. La citología permite su diagnóstico como una entidad benigna. En un contexto clínico y de imagen adecuado puede considerarse preoperatoriamente (AU)

Adenocarcinoma intestinal secundario de vejiga que simula clínicamente neoplasia primaria. Dos patrones clinicopatológicos diferenciados / Secondary adenocarcinoma of the bladder. Two differentiated clinicopathological patterns

Los adenocarcinomas secundarios de vejiga urinaria son tumores infrecuentes, y representan menos del 2% de todas las neoplasias malignas de vejiga. El origen colorrectal es el más habitual. La infiltración vesical secundaria puede suceder por extensión directa o por metástasis a distancia. Desde el punto de vista clínico, suelen manifestarse como los tumores vesicales primarios, y en el estudio histológico inicial plantean un desafío morfológico con los adenocarcinomas primitivos de vejiga urinaria. El presente estudio analiza las características clinicopatológicas de estas 2 formas de afectación vesical secundaria, y propone el uso de un panel inmunohistoquímico básico para el diagnóstico diferencial de estos adenocarcinomas. El diagnóstico específico de adenocarcinoma primario frente a infiltración vesical secundaria (invasión directa o metastásica) tiene relevantes connotaciones pronósticas y es decisivo en la toma de decisiones terapéuticas (AU)

Secondary adenocarcinoma of the urinary bladder is rare, representing less than 2% of all malignant bladder neoplasms. The most common origin of the primary tumour is colorectal. The bladder may be affected either by direct invasion or metastases. Secondary tumours present in the same way as primary bladder neoplasms and the initial histopathological diagnosis can prove challenging. The present study analyzes the clinicopathological features of both types of secondary bladder involvement and proposes the use of a basic immunohistochemical panel for their differential diagnosis. A correct differential diagnosis between primary adenocarcinoma of the bladder and secondary infiltration by either direct invasion or metastasis is important for both prognosis and therapy (AU)

Micropapillary carcinoma of the urinary tract: a cytologic study of urine and fine-needle aspirate samples.

OBJECTIVE: Micropapillary carcinoma (MPC) is an aggressive variant of urothelial carcinoma that needs early and specific recognition. In order to determine whether this tumor variant can be recognized with cytology, we evaluated a large cytohistological series. STUDY DESIGN: It was a retrospective cytohistological correlation study including 20 patients with MPC. Only those cases in which the tumor exhibited >50% of micropapillary growth were selected. Twenty exfoliative urine specimens and four needle aspirates from lymph node metastases were reviewed. RESULTS: On histology, 14 cases were infiltrative, while 6 were exclusively superficial. Cytology was characterized by numerous small, cohesive groups and single neoplastic cells. Pseudopapillae were present in 17 cases and in 9 they were a relevant finding. Morules were present in 15 cases. Isolated microacini were seen in 14 cases. Infiltrative tumors showed more neoplastic groups. Cellular atypia was prominent in 17 cases. In 15 cases, a cytologic diagnosis of urothelial carcinoma was made. One case was diagnosed as adenocarcinoma. The remaining 4 cases were considered suspicious of malignancy. CONCLUSIONS: The peculiar morphology of MPC of the urinary tract is partially reflected on cytology, allowing in some cases a specific recognition. This is important since the aggressive behavior of this neoplasm needs rapid management and treatment.

Fine-needle aspiration cytology of mammary myofibroblastoma: a report of six cases.

OBJECTIVE: To evaluate cytologic features of mammary myofibroblastoma in order to establish the possibility of precise preoperative recognition. STUDY DESIGN: This was a multi-institutional study of 6 patients with myofibroblastoma (5 men and 1 woman) in which preoperatively fine-needle aspiration cytology was performed. Four cases showed classical histologic features, 1 corresponded to the cellular variant and the remaining 1 to the fibrous form. RESULTS: Except for 1 case, smears were cellular and distributed as irregular aggregates and single cells. Most groups showed a small amount of metachromatic stroma and capillaries. Cells retained cytoplasm and showed a spindle-to-plump oval morphology with moderate pleomorphism. Nuclear pleomorphism was present and was relevant in 1 case. Intranuclear pseudoinclusions and mast cells were present in 3 cases. No epithelial clusters were seen. Due to hypercellularity and pleomorphism 1 case was considered as suspicious for malignancy. The remaining 5 were diagnosed as low-grade mesenchymal lesions, and myofibroblastoma was suggested in 3. CONCLUSION: Cytologic features of myofibroblastoma reflect what is seen on histology. When such findings are correlated with image studies, preoperative recognition can be possible. This is especially true for male patients in whom the tumor is relatively frequent.

Carcinoma mucinoso tubular y fusocelular renal. Descripción de los hallazgos citológicos de un caso pobre en mucina / Mucinous tubular and spindle cell renal carcinoma. Cytological findings in a case with poor mucin content

La clasificación de la OMS 2004 describe el carcinoma renal mucinoso tubular y fusocelular (CRMTF), como una neoplasia de bajo grado, que histológicamente se caracteriza por presentar en distintas proporciones, un estroma mucinoso y una población de células cuboides y fusiformes dispuestas en túbulos y fascículos. El diagnóstico citológico de este carcinoma se sustenta en identificar en los extendidos una proliferación celular de bajo grado sobre un fondo mixoide. Recientemente han sido descritas variantes pobres en mucina del CRMTF y que, junto a las formas clásicas, completan el espectro morfológico del tumor. En estos casos, el diagnóstico citológico se ve dificultado ante la ausencia o escasez de sustancia mixoide. En este artículo se presenta un nuevo caso de CRMTF variante pobre en mucina de predominio tubular, con especial mención al cuadro citológico. Las características citológicas de esta variante específica no han sido descritas previamente en la literatura. El cuadro descrito contribuye a completar el espectro citológico que puede adoptar el CRMTF(AU)

The 2004 WHO classification describes mucinous tubular and spindle cell renal carcinoma (MTSC) as a low grade neoplasm with a characteristic histological picture of varying proportions of mucinous stroma and cuboid and spindle cells arranged in tubules and fascicles. The cytological diagnosis of this carcinoma is made by identifying low grade cellular proliferation against a myxoid background. Recently, MTSC variants with poor mucin content have been described which, together with the classical forms, complete the morphological spectrum of this tumour. In these cases, the cytological diagnosis is difficult due to the absence or scarcity of the myxoid component. We present a case of a new, predominantly tubular, MTSC variant which had a poor mucin content. Special emphasis is placed on the cytological findings of this previously unreported variant which completes the cytological range of appearances that can be adopted by MTSC(AU)